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dnmpcpp dntp analogues  (Jena Bioscience)


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    Jena Bioscience dnmpcpp dntp analogues
    a SEC-MALLS analysis of SAMHD1 monomer–dimer–tetramer equilibrium upon addition of <t>dNMPCPP</t> nucleotides. In each panel, the solid lines are the chromatograms from the output of the differential refractometer and the black scatter points are the weight-averaged molar masses determined at 1-s intervals throughout elution of chromatographic peaks. In each panel, the displayed curves are: (red) apo-SAMHD1; (blue) SAMHD1 and 0.2 mM GTP; and (black) SAMHD1, 0.2 mM GTP and 0.5 mM indicated dNMPCPP analogue. b Bar chart of the apparent k cat values derived from 1 H NMR data recorded for GTP-stimulated SAMHD1 hydrolysis of each <t>dNTP,</t> dNMPCPP and dNMPCPP/dATP reaction, see Supplementary Fig. . Points overlaid in each bar are the individual data measurements, the error bars represent the standard deviation (s.d.) from at least two independent measurements. The source data are provided in the Source Data file.
    Dnmpcpp Dntp Analogues, supplied by Jena Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 26 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dnmpcpp dntp analogues/product/Jena Bioscience
    Average 93 stars, based on 26 article reviews
    dnmpcpp dntp analogues - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis"

    Article Title: Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

    Journal: Nature Communications

    doi: 10.1038/s41467-020-16983-2

    a SEC-MALLS analysis of SAMHD1 monomer–dimer–tetramer equilibrium upon addition of dNMPCPP nucleotides. In each panel, the solid lines are the chromatograms from the output of the differential refractometer and the black scatter points are the weight-averaged molar masses determined at 1-s intervals throughout elution of chromatographic peaks. In each panel, the displayed curves are: (red) apo-SAMHD1; (blue) SAMHD1 and 0.2 mM GTP; and (black) SAMHD1, 0.2 mM GTP and 0.5 mM indicated dNMPCPP analogue. b Bar chart of the apparent k cat values derived from 1 H NMR data recorded for GTP-stimulated SAMHD1 hydrolysis of each dNTP, dNMPCPP and dNMPCPP/dATP reaction, see Supplementary Fig. . Points overlaid in each bar are the individual data measurements, the error bars represent the standard deviation (s.d.) from at least two independent measurements. The source data are provided in the Source Data file.
    Figure Legend Snippet: a SEC-MALLS analysis of SAMHD1 monomer–dimer–tetramer equilibrium upon addition of dNMPCPP nucleotides. In each panel, the solid lines are the chromatograms from the output of the differential refractometer and the black scatter points are the weight-averaged molar masses determined at 1-s intervals throughout elution of chromatographic peaks. In each panel, the displayed curves are: (red) apo-SAMHD1; (blue) SAMHD1 and 0.2 mM GTP; and (black) SAMHD1, 0.2 mM GTP and 0.5 mM indicated dNMPCPP analogue. b Bar chart of the apparent k cat values derived from 1 H NMR data recorded for GTP-stimulated SAMHD1 hydrolysis of each dNTP, dNMPCPP and dNMPCPP/dATP reaction, see Supplementary Fig. . Points overlaid in each bar are the individual data measurements, the error bars represent the standard deviation (s.d.) from at least two independent measurements. The source data are provided in the Source Data file.

    Techniques Used: Derivative Assay, Standard Deviation



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    dnmpcpp dntp analogues  (Jena Bioscience)
    93
    Jena Bioscience dnmpcpp dntp analogues
    a SEC-MALLS analysis of SAMHD1 monomer–dimer–tetramer equilibrium upon addition of <t>dNMPCPP</t> nucleotides. In each panel, the solid lines are the chromatograms from the output of the differential refractometer and the black scatter points are the weight-averaged molar masses determined at 1-s intervals throughout elution of chromatographic peaks. In each panel, the displayed curves are: (red) apo-SAMHD1; (blue) SAMHD1 and 0.2 mM GTP; and (black) SAMHD1, 0.2 mM GTP and 0.5 mM indicated dNMPCPP analogue. b Bar chart of the apparent k cat values derived from 1 H NMR data recorded for GTP-stimulated SAMHD1 hydrolysis of each <t>dNTP,</t> dNMPCPP and dNMPCPP/dATP reaction, see Supplementary Fig. . Points overlaid in each bar are the individual data measurements, the error bars represent the standard deviation (s.d.) from at least two independent measurements. The source data are provided in the Source Data file.
    Dnmpcpp Dntp Analogues, supplied by Jena Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/dnmpcpp dntp analogues/product/Jena Bioscience
    Average 93 stars, based on 1 article reviews
    dnmpcpp dntp analogues - by Bioz Stars, 2026-03
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    a SEC-MALLS analysis of SAMHD1 monomer–dimer–tetramer equilibrium upon addition of dNMPCPP nucleotides. In each panel, the solid lines are the chromatograms from the output of the differential refractometer and the black scatter points are the weight-averaged molar masses determined at 1-s intervals throughout elution of chromatographic peaks. In each panel, the displayed curves are: (red) apo-SAMHD1; (blue) SAMHD1 and 0.2 mM GTP; and (black) SAMHD1, 0.2 mM GTP and 0.5 mM indicated dNMPCPP analogue. b Bar chart of the apparent k cat values derived from 1 H NMR data recorded for GTP-stimulated SAMHD1 hydrolysis of each dNTP, dNMPCPP and dNMPCPP/dATP reaction, see Supplementary Fig. . Points overlaid in each bar are the individual data measurements, the error bars represent the standard deviation (s.d.) from at least two independent measurements. The source data are provided in the Source Data file.

    Journal: Nature Communications

    Article Title: Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

    doi: 10.1038/s41467-020-16983-2

    Figure Lengend Snippet: a SEC-MALLS analysis of SAMHD1 monomer–dimer–tetramer equilibrium upon addition of dNMPCPP nucleotides. In each panel, the solid lines are the chromatograms from the output of the differential refractometer and the black scatter points are the weight-averaged molar masses determined at 1-s intervals throughout elution of chromatographic peaks. In each panel, the displayed curves are: (red) apo-SAMHD1; (blue) SAMHD1 and 0.2 mM GTP; and (black) SAMHD1, 0.2 mM GTP and 0.5 mM indicated dNMPCPP analogue. b Bar chart of the apparent k cat values derived from 1 H NMR data recorded for GTP-stimulated SAMHD1 hydrolysis of each dNTP, dNMPCPP and dNMPCPP/dATP reaction, see Supplementary Fig. . Points overlaid in each bar are the individual data measurements, the error bars represent the standard deviation (s.d.) from at least two independent measurements. The source data are provided in the Source Data file.

    Article Snippet: XTP, and dNMPNPP and dNMPCPP dNTP analogues were purchased from Jena Bioscience, DE.

    Techniques: Derivative Assay, Standard Deviation